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The purposes of this study are to evaluate the efficacy of topical methocarbamol (acetylmethadol hydrochloride) for the treatment of experimental postoperative pain in cats and to determine if there is an optimal concentration for the treatment. Outcomes of interest included the degree of pain relief, duration of pain relief, onset and duration of postsurgical analgesia, onset of sedation, and emergence from anesthesia. Two groups of 10 cats were used, each randomly assigned to receive saline (control), 1.25%, 3.5%, 7.0%, or 10.0% methocarbamol (treatment) administered either topically or intravenously. Following placement of dorsal lumbosacral laminectomy sites in the cat, a standardized bone flap procedure was performed to measure incisional pain in treatment and control groups. All cats received diclofenac sodium (10 mg/kg i.m.). Cats were administered 5 mg/kg i.v. methocarbamol (treatment) or saline (control) followed by 2 mg/kg i.m. methocarbamol or saline at 60, 120, 240, and 360 min. In the treatment groups, titration occurred following a minimum of 60 min of fentanyl (100 mcg/kg i.m.) or 30 min of xylazine (5 mg/kg i.v.). Follow-up visits occurred 8, 12, 24, 48, and 72 h after surgery. Analgesia was evaluated by pin prick; pain relief was evaluated by a modified synovial fistula inflammatory pain model; sedation was evaluated by the inhaled isoflurane narcosis and locomotor activity was evaluated by a previously published observational pain-relief scoring technique. Morphine (2 mg/kg i.v.) was administered to cats after the 72-h follow-up period to assess the duration of pain relief. At the 1-h follow-up, mean values for pain relief and sedation were significantly higher in the 1.25% and 3.5% methocarbamol groups than control. At the 12-h follow-up, all treatment groups (1.25%, 3.5%, 7.0%, 10.0%) had significantly higher mean values than control for pain relief and sedation. In the 10.0% methocarbamol group, mean values for pain relief at the 8-h follow-up were significantly higher than control. At
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